Preprints

Aguirre CG, Woo JH, Alhabbal L, Fujioka T, Moore R, Ye T, Castrellon JJ, Soltani A, Izquierdo A. Sex differences in task engagement and lapse rate during reward learning, bioRxiv 2025.10.29.685451.

2025

Rivera ZMG, Guerrero Leon K, Cervera M, Aguayo B, Izquierdo A, Wikenheiser AM (2025). A progressive ratio task with costly resets reveals adaptive effort-delay tradeoffs. eNeuro 12(11) ENEURO.0258-25.2025.

Romero-Sosa JL, Wikenheiser AM, Blair HT, Izquierdo A (2024). Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex. Nat Commun 16 (8931) https://doi.org/10.1038/s41467-025-63866-5.

González VV, Malvaez M, Yeghikian A, Wissing S, Sharpe M, Wassum KM, Izquierdo A (2024). A common stay-on-goal mechanism in anterior cingulate cortex for information and effort choices. eNeuro 12 (3) ENEURO.0454-24.2025.

2024

González VV, Zhang Y, Ashikyan SA, Rickard A, Yassine I, Romero-Sosa JL, Blaisdell AP, Izquierdo A (2024). A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information. Cerebral Cortex 34(4): bhae135.

Aguirre CG, Woo JH, Romero-Sosa JL, Rivera ZM, Tejada AN, Munier JJ, Perez J, Goldfarb M, Das K, Gomez M, Ye T, Pannu J, Evans K, O’Neill PR, Spigelman I, Soltani A, Izquierdo A (2024). Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty. The Journal of Neuroscience 44(2): e0622232023.

2023

Ye T, Romero-Sosa JL, Rickard A, Aguirre CG, Wikenheiser AM, Blair HT, Izquierdo A (2023). Theta oscillations in anterior cingulate cortex and orbitofrontal cortex differentially modulate accuracy and speed in flexible reward learning. Oxford Open Neuroscience 2: kvad005.

Woo JH, Aguirre CG, Bari BA, Tsutsui K, Grabenhorst F, Cohen JY, Schultz W, Izquierdo A, Soltani A (2023). Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys. Cognitive, Affective and Behavioral Neuroscience 23(3): 600-619. 

González VV, Izquierdo A, Blaisdell A (2023). Theoretical mechanisms of paradoxical choices involving information. Comparative Cognitive & Behavior Reviews, in press.

Chen Z, Blair GJ, Guo C, Zhou J, Romero-Sosa JL, Izquierdo A, Golshani P, Cong J, Aharoni D, Blair HT (2023). A hardware system for real-time decoding of in vivo calcium imaging data. eLife 12:e78344.

2022

Rudebeck PH and Izquierdo A (2022). Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior. Neuropsychopharmacology 47: 134–146.

2021

Nieto SJ, Grodin EN, Aguirre C, Izquierdo A, Ray LA (2021). Translational opportunities in animal and human models to study alcohol use disorder. Translational Psychiatry in press.

Romero Sosa, JL, Buonomano D, Izquierdo A (2021). The Orbitofrontal Cortex in Temporal Cognition. Behavioral Neuroscience 135(2): 154-164.

Harris C*, Aguirre CG*, Kolli S, Das K, Izquierdo A#, Soltani A# (2021). Unique features of stimulus-based probabilistic reversal learning. Behavioral Neuroscience  135(4):550-570.   *co-first authors #co-senior authors

2020

Aguirre CG, Stolyarova A, Das K, Kolli S, Marty V, Ray L, Spigelman I, Izquierdo A (2020). Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal. PLoSONE 15(6): e0234729.

Hart EE*, Blair GJ*, O’Dell TJ, Blair HT, Izquierdo A (2020). Chemogenetic modulation and single-photon calcium imaging in anterior cingulate cortex reveal a mechanism for effort-based decisions. The Journal of Neuroscience 40 (29) 5628-5643.  *co-first authors

2019

Stolyarova A*, Rakhshan M*, Hart EE, O’Dell TJ, Peters MAK, Lau H, Soltani A, Izquierdo A (2019). Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty. Nature Communications 10: 4704. *co-first authors

Soltani A and Izquierdo A (2019). Adaptive learning under expected and unexpected uncertainty. Nat Rev Neurosci doi: 10.1038/s41583-019-0180-y.

Hart EE and Izquierdo A (2019). Quantity versus quality: Convergent findings in effort-based choice tasks. Behavioural Processes 164: 178-185.

Izquierdo A, Aguirre C, Hart EE, Stolyarova A (2019). Animal models of adaptive learning and decision making. Psychiatric Disorders (2nd Edition) Methods Mol Biol 2011:105-119.

2018

Hart EE, Gerson JO, Izquierdo A (2018). Persistent effect of withdrawal from intravenous methamphetamine self-administration on brain activation and behavioral economic indices involving an effort cost. Neuropharmacology 140: 130-138.

2017

Izquierdo (2017). Functional heterogeneity within rat orbitofrontal cortex in reward learning and decision making. The Journal of Neuroscience 37(44): 10529-10540.

Stolyarova A and Izquierdo A (2017). Complementary contributions of basolateral amygdala and orbitofrontal cortex to value learning under uncertainty. eLife https://elifesciences.org/articles/27483.

Thompson AB, Gerson J, Stolyarova A, Bugarin A, Hart EE, Jentsch JD, Izquierdo A (2017). Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats. Psychopharmacology 234(18): 2697-2705.

Hart EE, Gerson JO, Zoken Y, Garcia M, and Izquierdo A (2017). Anterior cingulate cortex supports effort allocation toward a qualitatively preferred option. Eur J Neurosci 46(1): 1682-1688.

Hart EE and Izquierdo A (2017). Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option. Eur J Neurosci 45(3): 388-397.

Hart EE, Stolyarova A, Conoscenti M, Minor TR, Izquierdo A (2017). Rigid patterns of effortful choice behavior after acute stress in rats. Stress 20(1): 19-28.

2016 and earlier

Izquierdo A, Pozos H, De La Torre A, DeShields S, Cevallos J, Rodriguez J, Stolyarova A (2016). Sex differences, learning flexibility, and striatal D1 and D2 following adolescent drug exposure in rats. Behavioural Brain Research 308: 104-14.

Izquierdo A, Radke AK, Brigman JL, Rudebeck PH, Holmes A (2016). The neural basis of reversal learning: An updated perspective. Neuroscience doi: 10.1016/j.neuroscience.2016.03.021.

Izquierdo A and Silva AJ (2016). Hijacking translation in addiction. eLife doi: 10.7554/eLife.14576.

Wassum KM & Izquierdo A (2015). The basolateral amygdala in reward learning and addiction. Neuroscience and Biobehavioral Reviews 57: 271-283.

Thompson AB, Stolyarova A, Ying Z, Zhuang Y, Gómez-Pinilla F, Izquierdo A (2015). Methamphetamine blocks exercise-induced increases in Bdnf and Drd2 gene expression in frontal cortex and striatum. Neuropharmacology 99: 658-664.

Stolyarova A and Izquierdo A (2015). Distinct patterns of reward valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood. Frontiers in Behavioral Neuroscience doi: 10.3389/fnbeh.2015.00115.

Ochoa JG, Stolyarova A, Kaur A, Hart EE, Bugarin A, Izquierdo A (2015). Post-training depletions of basolateral amygdala serotonin fail to disrupt discrimination, retention, or reversal learning. Frontiers in Neurosciencedoi: 10.3389/fnins.2015.00155.

Stolyarova A, Thompson AB, Barrientos RM, Izquierdo A (2015). Reductions in frontocortical cytokine levels are associated with long-lasting alterations in reward valuation after methamphetamine. Neuropsychopharmacology 40: 1234-1242.

Stolyarova A, O’Dell SJ, Marshall JF, Izquierdo A (2014). Responses to positive and negative feedback and associated dopamine and serotonin transporter binding after methamphetamine. Behavioural Brain Research 271: 195-202.

Ye T, Pozos H, Phillips TJ, Izquierdo A (2014). Long-term effects of exposure to methamphetamine in adolescent rats. Drug and Alcohol Dependence 138: 17-23.

Izquierdo A, Darling C, Manos N, Pozos H, Kim C, Ostrander S, Cazares V, Stepp H, Rudebeck PH (2013). Basolateral amygdala lesions facilitate reward choices after negative feedback in rats. The Journal of Neuroscience 33(9): 4105-9.

Kosheleff AR, Rodriguez D, O’Dell SJ, Marshall JF, Izquierdo A (2012). Comparison of single-dose and escalating methamphetamine administration on reversal learning in rats. Psychopharmacology, 224(3):459-67.

Izquierdo A, Carlos K, Ostrander S, Rodriguez D, McCall-Craddolph A, Yagnik G, Zhou F (2012). Impaired reward learning and intact motivation after serotonin depletion in rats. Behavioural Brain Research, 233 (2): 494-9.

Izquierdo A and Jentsch JD (2012). Reversal learning as a measure of impulsive and compulsive behavior in addictions. In: Robbins, TW (Ed.) Impulsivity and Compulsivity. Psychopharmacology special issue, 219 (2): 607-20

Izquierdo A and Belcher AM (2012). Rodent models of adaptive decision making. In: Kobeissy FH (Ed.) Psychiatric Disorders: Methods Mol Biol, Humana Press, New York, 829: 85-101.

Kosheleff AR, Grimes M, O’Dell SJ, Marshall JF, Izquierdo A. (2012). Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats. Psychopharmacology, 219(2): 411-20.

Ostrander S, Cazares VA, Kim C, Cheung S, Gonzalez I, Izquierdo A. (2011). Orbitofrontal cortex and basolateral amygdala lesions result in suboptimal and dissociable reward choices on cue-guided effort in rats. In: Baxter, MG (Ed.), Translating Models in Prefrontal Cortex Function between Animals and Humans. Behavioral Neuroscience, 125(3): 350-359.

Izquierdo A, Belcher AM, Scott L, Cazares VA, Chen J, O’Dell SJ, Malvaez M, Wu T, and Marshall JF (2010) Reversal-specific learning impairments following a binge regimen of methamphetamine in rats: Possible involvement of striatal dopamine. Neuropsychopharmacology 35: 505-514.